Monday Night Football odds, line, time, spread: Jaguars vs. Bills picks from Jacksonville expert on 41-18 roll

Mike Tierney, who is 41-18 on Jacksonville picks, has revealed his Monday Night Football doubleheader best bets for Buffalo vs. Jacksonville

The Buffalo Bills (2-0) will try to stay undefeated when they host the Jacksonville Jaguars (0-2) in the first of two Monday Night Football games. The Bills will be under the bright lights a lot this season. In fact, Buffalo has five primetime games on their slate and beat the Dolphins in the Week 2 Thursday Night Football game. Meanwhile, the Jaguars have two total primetime games, this being the first. Buffalo is averaging 32.5 points per game, while Jacksonville puts up just 15 per contest.

Kickoff from at Highmark Stadium in Buffalo, NY., is set for 7:30 p.m. ET. Buffalo is a 5.5-point favorite in the latest Jaguars vs. Bills odds via SportsLine consensus, while the over/under for total points scored is 45.5. Before locking in any Bills vs. Jaguars picks, make sure to check out the NFL predictions and betting advice from the SportsLine expert Mike Tierney.

A veteran sportswriter whose work appears periodically in the New York Times and Los Angeles Times, Mike Tierney has covered the NFL for decades and reported from seven Super Bowls. Mike is 154-124-9 in the NFL the past two seasons, returning $1,586 to $100 players. Tierney also has a strong read on the Jags. In fact, he is 41-18 (+2161) on his last 59 NFL picks in games involving Jacksonville. Anyone who has followed him is way up.

Now, Tierney has locked in on Jaguars vs. Bills and just revealed his coveted NFL picks and sports betting predictions. You can head to SportsLine now to see his picks. Here are several NFL odds and NFL betting lines on the spread, money line and over/under for Bills vs. Jaguars:

• Jaguars vs. Bills spread: Buffalo -5.5
• Jaguars vs. Bills over/under: 45.5 points
• Jaguars vs. Bills money line: Buffalo -250, Jacksonville +203
• BUF: Bills have hit the 2Q money line in 10 of their last 19 games
• JAX: Jaguars have covered the 1H spread in 13 of their last 21 games
• Jaguars vs. Bills picks: See picks at SportsLine

Why the Bills can cover

Defensive end Greg Rousseau generates havoc in the backfield for opposing clubs. Rousseau has a blend of speed and power to blow past linemen. In two games, the Miami (FL) product has 10 total tackles, four tackles for loss, three sacks, and one forced fumble. Linebacker Von Miller seems to have plenty of juice this season and is giving Buffalo a spark. Miller has four tackles and two sacks this season.

Linebacker Dorian Williams has been thrust into the fire but has been a stable presence around the ball. The Tulane product owns good play recognition skills and wraps up well. The 23-year-old leads the team in total tackles (19) with one fumble recovery. He had a career-high 10 stops in his last outing. See who to back at SportsLine.

Why the Jaguars can cover

Linebacker Foyesade Oluokun plays the game with relentless energy. Oluokun has strong game speed and is able to fly to the ball with ease due to instincts and sound awareness. He leads the team in total tackles (19) and tackles for loss (3). The 29-year-old has logged at least eight tackles in consecutive games.

Defensive end Travon Walker is an athletic rusher around the corner. Walker has a blazing get-off to blow past blockers. The Georgia product has eight tackles and a team-high two sacks. Defensive end Josh Hines-Allen provides the Jags with another disruptive presence up front. Hines-Allen has 54 tackles for loss, 46 sacks, and nine forced fumbles in his career. See who to back at SportsLine.

How to make Jaguars vs. Bills picks

Tierney has analyzed Bills vs. Jaguars from every possible angle and while we can tell you he's leaning Over the point total, he has also discovered a critical X-factor that has him jumping all over one side of the spread. Find out what it is at SportsLine. 

So who wins Bills vs. Jaguars on Monday Night Football, and what critical x-factor makes one side hit hard? Visit SportsLine now to see which side of the Bills vs. Jaguars spread to back, all from the expert who is 41-18 on picks involving Jacksonville, and find out.