Giants vs. Cowboys odds, prediction, time, spread: Thursday Night Football picks from NFL model on 42-22-roll

SportsLine's model simulated Dallas Cowboys vs. New York Giants on Thursday Night Football 10,000 times

NFC East rivals will clash when the Dallas Cowboys face the New York Giants on Thursday Night Football at MetLife Stadium. Dallas will be out to snap a two-game losing streak after dropping a 28-25 decision to the Baltimore Ravens last Sunday, while New York is eyeing a second consecutive win after defeating Cleveland, 21-15. The Cowboys (1-2), who are hoping to win their third NFC East crown in four years, have beaten New York 13 of the past 14 times they have met, including three in a row at MetLife. The Giants (1-2), who have not won a division crown since 2011, are looking to build on last year's third-place finish and 6-11 record.

Kickoff from MetLife Stadium in East Rutherford, N.J., is set for 8:15 p.m. ET. The Cowboys are 4.5-point favorites in the latest Giants vs. Cowboys odds, while the over/under for total points scored is 44. Before making any Cowboys vs. Giants picks, be sure to see the NFL predictions and betting advice from SportsLine's proven computer model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 4 of the 2024 NFL season on an incredible 188-130 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 42-22 roll on top-rated NFL picks since Week 7 of 2022.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.    

Now, the model has set its sights on Cowboys vs. Giants and just locked in its picks and NFL predictions. You can head to SportsLine now to see the model's picks. Here are several NFL odds and NFL betting lines for the spread, money line and over/under for Giants vs. Cowboys: 

• Giants vs. Cowboys spread: Dallas -4.5
• Giants vs. Cowboys over/under: 44 points
• Giants vs. Cowboys money line: Dallas -216, New York Giants +178
• DAL: Cowboys are 5-5 on the road since the start of 2023
• NYG: Giants are 4-5 at MetLife Stadium since the beginning of last season
• Giants vs. Cowboys picks: See picks at SportsLine

Why you should back the Cowboys

Ninth-year veteran quarterback Dak Prescott continues to be the key to Dallas' offense. In last Sunday's loss to the Baltimore Ravens, he completed 28 of 51 passes (54.9%) for 379 yards and two touchdowns. He also carried twice for seven yards and a score. For the season, he has connected on 60.7% of his passes for 851 yards and four touchdowns with two picks and an 85.8 rating.

The rushing attack is led by the combination of veteran running backs Rico Dowdle and Ezekiel Elliott. Dowdle is the top rusher, carrying 23 times for 88 yards (3.8 average), and has caught eight passes for 59 yards (7.4 average). Elliott, meanwhile, has 19 carries for 62 yards (3.3 average) and one touchdown. He also has five receptions for 31 yards (6.2 average). See which team to pick here.

Why you should back the Giants

Sixth-year veteran quarterback Daniel Jones heads up the New York offense. In three starts, he has completed 62 of 104 passes (59.6%) for 600 yards and four touchdowns with two interceptions. He also has 19 carries for 67 yards (3.5 average) and four first-down conversions. In Sunday's win at Cleveland, Jones completed 24 of 34 passes (70.6%) for 236 yards and two touchdowns.

His top target has been first-round draft pick Malik Nabers. In three games, he has 23 receptions on 37 targets for 271 yards (11.8 average) and three touchdowns. He had eight catches for 78 yards and two touchdowns in the win over the Browns. He had 10 catches for 127 yards and one score in the loss at Washington in Week 2. See which team to pick here.

How to make Cowboys vs. Giants picks

SportsLine's model is leaning Over on the total. It has also generated an against-the-spread pick that hits in well over 50% of simulations. You can only get the NFL model's picks at SportsLine.

So who wins Cowboys vs. Giants on Thursday Night Football, and which side of the spread cashes in well over 50% of simulations? Visit SportsLine now to see which side of the Cowboys vs. Giants spread to jump on, all from the advanced model that is up well over $7,000 on its NFL picks, and find out.