Penn State vs. USC odds, line, spread: 2024 college football picks, Week 7 predictions by proven model

SportsLine's model revealed its CFB picks and predictions for USC Trojans vs. Penn State Nittany Lions on CBS and Paramount+

A new Big Ten rivalry begins during the Week 7 college football schedule as the No. 4 Penn State Nittany Lions (5-0) travel to take on the USC Trojans (3-2) on CBS and Paramount+. Penn State is off to a 2-0 start in Big Ten play and is currently well-situated to be in the College Football Playoff mix. USC, meanwhile, has dropped two of its first three Big Ten games, including losing as an 8.5-point favorite at Minnesota last week, making this an urgent spot for USC. This is the first meeting between the programs since USC defeated Penn State 52-19 in the 2017 Rose Bowl.

Kickoff from LA Memorial Coliseum is set for 3:30 p.m. ET. The Nittany Lions are 3.5-point favorites in the latest Penn State vs. USC odds via SportsLine consensus. The over/under is 50.5, down from opening at 53.5. Before making any USC vs. Penn State picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

Saturday's game can be seen live on CBS and streamed live on Paramount+, which you can now get for a 7-day free trial. Sign up right here.

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a profit of well over $2,000 for $100 players on its top-rated college football picks against the spread. It's also on an 8-4 run on top-rated college football picks over the past two weeks. Anyone who has followed it has seen strong returns.

Now, the model has dialed in on Penn State vs. USC and just revealed its coveted picks and predictions. You can head to SportsLine now to see the model's picks. Here are the college football odds for the spread, money line and over/under:

• Penn State vs. USC spread: Penn State -3.5
• Penn State vs. USC over/under: 50.5 points 
• Penn State vs. USC money line: Penn State -179, USC +148
• Penn State vs. USC picks: See picks at SportsLine
• Penn State vs. USC streaming: Paramount+ (Get seven days free)

Why Penn State can cover

Junior quarterback Drew Allar deserves a lot of credit for Penn State's perfect start. He's completing 70.9% of his passes for 1,101 yards and nine touchdowns. He's done a great job of limiting mistakes, throwing just one interception and taking only six sacks on the season.

Penn State's rushing offense ranks third in the Big Ten and it is hopeful to get running back Nicholas Singleton back this week after he missed Week 6 with an undisclosed injury. Head coach James Franklin said he's optimistic that he'll be able to play this week. Singleton teams up with bruiser Kaytron Allen to spearhead a rushing attack that averages 217.8 yards per game. USC, meanwhile, ranks 87th nationally in rushing defense. See picks at SportsLine.

Why USC can cover

Though Penn State is undefeated, the Nittany Lions had a close call against Bowling Green, a MAC squad, in Week 2, surviving 34-27. They also weren't overly impressive against UCLA, one of worst teams in the Big Ten, in Week 6, letting the Bruins stick around until late in the third quarter. 

USC's two losses have come on the road and now they're getting more than a field at home after the lookahead lines had USC around +1.5. Overall, USC's defense looks a lot better this year compared to 2023, and Riley's offense, while not clicking on all cylinders, is still averaging more than 30 points per game thus far. See picks at SportsLine.

How to make USC vs. Penn State picks

SportsLine's model is going Over on the total, projecting 56 combined points. It also says one side of the spread hits in nearly 60% of simulations. You can see the model's pick at SportsLine.

So who wins Penn State vs. USC, and which side of the spread hits nearly 60% of the time? Visit SportsLine now to see which side of the spread to jump on, all from the advanced model that is up well over $2,000 on top-rated spread picks since its inception, and find out, and don't forget to stream the game on Paramount+.