Lions vs. Seahawks odds, line, spread, prediction: Monday Night Football picks by NFL model on 188-130 roll

SportsLine's model has simulated Seattle Seahawks vs. Detroit Lions on Monday Night Football 10,000 times

For the second straight week, there will be two games on Monday Night Football. The Detroit Lions (2-1) will host the Seattle Seahawks (3-0) in the second game, and the primetime battle may have seeding implications late in the season for the NFC. The Seahawks lead the all-time series 13-5 over the Lions and have won six straight games. In the last meeting in 2023, Seattle beat Detroit, 37-31 in overtime.

Kickoff from Ford Field in Detroit is set for 8:15 p.m. ET. Detroit is a 4.5-point favorite in the latest Seahawks vs. Lions odds from the SportsLine Consensus, while the over/under for total points scored is 47. Before locking in any Seahawks vs. Lions picks, make sure to check out the NFL predictions and betting advice from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 4 of the 2024 NFL season on an incredible 188-130 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 42-22 roll on top-rated NFL picks since Week 7 of 2022.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has simulated Seahawks vs. Lions 10,000 times and just revealed its coveted NFL picks and Lions vs. Seahawks betting predictions. You can head to SportsLine now to see the model's picks. Here are several NFL odds and NFL betting lines for the spread, money line and over/under for Lions vs. Seahawks:

• Lions vs. Seahawks spread: Detroit -4.5
• Lions vs. Seahawks over/under: 47 points
• Lions vs. Seahawks money line: Detroit -209, Seattle +173
• SEA: Seahawks have covered the 1H spread in eight of their last 11 away games 
• DET: Lions have covered the spread in 16 of their last 21 games
• Lions vs. Seahawks picks: See picks at SportsLine

Why the Lions can cover

Quarterback Jared Goff is a strong player when he's in rhythm. Goff has superb accuracy and will push the ball downfield to his weapons. In four seasons with the Lions, the 29-year-old is completing 66% of his throws for 18,171 yards and 81 passing touchdowns. In his last outing, Goff went 18-of-23 for 199 yards and two passing touchdowns.

Receiver Amon-Ra St. Brown is a crafty route-runner who has hands like glue to secure any pass. St. Brown excels in the short and intermediate areas of the field. The USC product is tied for fourth in the league in receptions (21) and has 207 yards and one touchdown. Last week, the 24-year-old had seven receptions for 75 yards and his lone touchdown. See who to back at SportsLine.

Why the Seahawks can cover

Seattle has a bevy of capable playmakers who can make an impact in any matchup. Receiver DK Metcalf stands at 6-foot-4, but owns the speed to take the top off the defense. The two-time Pro Bowler is seventh in the NFL in receiving yards (262) with 17 receptions and two touchdowns. He's gone over 100 yards in back-to-back games. On Sept. 22 versus the Dolphins, Metcalf had four grabs for 104 yards and one touchdown.

Receiver Jaxon Smith-Njigba is a smooth and nimble route-runner. He thrives in the slot and will eat up targets underneath. The Ohio State product has logged 17 catches for 175 yards, and 10.3 yards per reception. He's gone over 50 yards six times in his career. In Week 2, Smith-Njigba has 12 receptions for 117 yards. See who to back at SportsLine.

How to make Lions vs. Seahawks picks

SportsLine's model is leaning Over on the total, projecting the teams to combine for 50 points. The model also says one side of the spread cashes in well over 50% of simulations. Head to SportsLine to see its NFL picks. 

So who wins Seahawks vs. Lions on Monday Night Football, and which side of the spread cashes well over 50% of the time? Visit SportsLine now to see which side of the Seahawks vs. Lions spread to back, all from the model that has returned well over $7,000 on top-rated NFL picks, and find out.