Self-learning AI generates NFL against the spread, over-under, money-line picks for every Week 4, 2024 game

SportsLine AI reveals its NFL predictions and NFL betting picks for all 16 NFL games in Week 4

Despite playing without Cooper Kupp, Puka Nacua and multiple offensive linemen, the Los Angeles Rams pulled off a 27-24 upset against the San Francisco 49ers in Week 3. However, they're still three-point underdogs on the road against the Chicago Bears in the Week 4 NFL odds. Chicago is coming off a 21-16 loss to the Colts and has battled shaky offensive line play all season, but the Rams only have four sacks and nine quarterback hits all season. Who wins in the trenches during Bears vs. Rams and how should you handle all 16 NFL spreads? Nailing your Week 4 NFL score predictions is all about understanding the NFL matchups and using NFL betting trends to make informed decisions. So before you make any Week 4 NFL picks, you need to see the NFL against the spread, over-under, and money line predictions powered by the self-learning SportsLine AI.

Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine's Data Science team, AI Predictions and AI Ratings are generated for each game. The AI predictions are determined by statistically learning from each team's historical data and then quantitatively evaluating the strength of the opponent's defense by assigning a numeric value out of 100 called a matchup score. 

Once a prediction is formulated, the AI rating is generated using the prediction, the matchup score, and the odds of the market. For example, you could see an A-rating on an over bet if a team is facing a poor defense, their prediction differs from the line and there are favorable odds.

In addition, SportsLine AI is the first fully automated predictive model at SportsLine. It continuously refreshes on the most recent available data and can help you spot the biggest discrepancies in the lines. Last season, SportsLine's AI PickBot hit a whopping 1,674 4.5- and 5-star prop picks. Anyone who has followed it is way up.

For Week 4 NFL betting, the AI PickBot has evaluated the NFL odds and provided NFL betting predictions for all 16 games. You can only see the AI predictions for the Week 4 NFL schedule here.

Top Week 4 NFL AI picks

After analyzing every game in Week 4, the AI PickBot says the Jaguars cover as 6.5-point road underdogs against the Texans. Jacksonville is off to an 0-3 start that was capped by an embarrassing 47-10 loss to the Bills on Monday Night Football. Doug Pederson's seat is getting hot because of the loss, but they have an opportunity to get back on track with a divisional win in Week 4.

Houston was also blown out in Week 3, losing 34-7 against the Vikings in a game in which the Texans were favored by 1.5 on the road. Now, they're spotting Jacksonville 6.5, but the Jaguars have gotten the better of the Texans two of the last three times they've played. That includes a 24-21 win in Houston last year in which Trevor Lawrence threw for 364 yards. The AI PickBot is expecting Joe Mixon's high-ankle sprain to play a role as well, predicting Houston wins 23-21 on average, with Jacksonville to cover graded as an A-rated pick. See its other Week 4 football predictions and football picks at SportsLine.

How to make Week 4 NFL picks

In addition, the AI PickBot has generated 11 other A-rated picks for Week 4. You need to see the AI PickBot's picks before making any Week 4 NFL bets of your own. You can only see them at SportsLine.

Who wins and covers each Week 4 NFL game, and which A-rated picks should you target?  Visit SportsLine now to see the top NFL picks against the spread, over-under, and on money line, all from the brand-new SportsLine AI PickBot that nailed 1,674 top-rated picks last season.