Study supports very early abortion for women seeking termination
· News-MedicalClinics and hospitals currently defer medication abortion until ultrasound confirms a pregnancy inside the uterus. However, a large international study led by researchers from Karolinska Institutet now indicates that treatment can be equally effective and safe even before the sixth week of pregnancy. The study is published in The New England Journal of Medicine.
Karin Brandell, study's first author, gynecologist at Karolinska University Hospital and doctoral student at the Department of Women's and Children's Health, Karolinska Institutet, SwedenWomen often find out very early if they're pregnant, and a majority also know if they want a termination and if so, want it to take place as quickly as possible. Observational studies have produced contradictory results as regards effectiveness, so we wanted to study if very early abortion is just as effective and safe as waiting."
Women from nine countries
The VEMA (Very early medical abortion) study included over 1,500 women at 26 clinics in nine countries who requested an abortion before ultrasound was able to confirm intrauterine pregnancy. They were randomly assigned to either a delayed abortion once pregnancy could be confirmed in the uterus (in week 5 to 6) or to early abortion (in week 4 to 6). Both groups received two drugs – mifepristone and misoprostol.
At the start of the study, all participants were up to six weeks pregnant and presented no symptoms of ectopic pregnancy (e.g. abdominal pain or bleeding) or risk factors for such a pregnancy (e.g. pregnancy despite a coil or previous ectopic pregnancies). The outcome measure was terminated pregnancy (complete abortion).
"Very early medical abortion was just as effective and safe to perform, even in case of an undiagnosed ectopic pregnancy," says Kristina Gemzell-Danielsson, professor of obstetrics and gynaecology at the same department at Karolinska Institutet, senior physician at Karolinska University Hospital and project leader of the VEMA study.
A political issue
The women in the early group reported less pain and bleeding. In both groups, the women also expressed a desire to have the abortion performed as quickly as possible.
"Abortion is a political as well as a medical issue," says Dr Brandell. "In Sweden, a woman can repeat the procedure a week after a failed early abortion. But a woman in Texas, where abortion is banned after the sixth week, can't. It was therefore important to show that early abortion is equivalent to current standard procedure at a later stage of pregnancy."
Better abortions and contraceptives
The researchers now want to test if a new combination of drugs for early abortion is also effective for ectopic pregnancies. They are also developing new contraceptives based on one of the components of current medical abortions, mifepristone.
"It can be taken in a lower dose than for abortion to prevent unwanted pregnancies in the form of one tablet a week, or when needed," says Professor Gemzell-Danielsson.
The study was supported by grants from the Swedish Research Council, research funds of the Hospital System of Helsinki and Uusimaa, the European Society of Contraception and Reproductive Health, the Nordic Federation of Societies of Obstetrics and Gynecology, the Gothenburg Society of Medicine, and an ALF grant (Karolinska Institutet/Region Stockholm). The researchers' conflicts of interests are reported in full in the study.
Source:
Journal reference: