Clemson vs. Louisville odds, spread, line: 2024 college football picks, Week 10 predictions from proven model

SportsLine's model just revealed its college football picks for Louisville Cardinals vs. Clemson Tigers on Saturday

The No. 11 Clemson Tigers look to make their way back into the top 10 in the polls and keep pace atop the ACC standings when they play the Louisville Cardinals in ACC action on Saturday night. Clemson improved to 6-1 overall and 5-0 in the ACC with a 48-31 win over Virginia on Oct. 19 before its bye week. Louisville improved to 5-3 overall and 3-2 in the ACC with a 31-27 victory over Boston College on Oct. 25. The Cardinals outscored Boston College, 14-0, in the fourth quarter in the comeback victory and hope to carry that momentum to upset a ranked Clemson squad.

The game is scheduled to kick off from Memorial Stadium (Death Valley) in Clemson, S.C., at 7:30 p.m. ET on Saturday. Clemson is a 10.5-point favorite in the latest Louisville vs. Clemson odds, while the over/under is 62 points, per SportsLine consensus. Before entering any Clemson vs. Louisville picks, you'll want to see the college football predictions from the model at SportsLine.

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and it is a sizzling 16-7 on all top-rated picks over the past five weeks of this season. Anyone following at sportsbooks and on betting apps has seen strong returns.

The model has set its sights on Louisville vs. Clemson. You can head to SportsLine to see its picks. Here are several college football betting lines from sports betting sites for Clemson vs. Louisville:

• Clemson vs. Louisville spread: Clemson -10.5
• Clemson vs. Louisville over/under: 62 points
• Clemson vs. Louisville money line: Clemson -408, Louisville +311
• Clemson vs. Louisville picks: See picks here
• Clemson vs. Louisville streaming: FuboTV (Try for free)

Why Louisville can cover

The Cardinals are coming off a huge fourth quarter and second half in their comeback victory on the road against Boston College last week. Louisville scored all 14 of the game's fourth-quarter points and outscored Boston College, 24-7, in the second half. Even after Tyler Shough threw what could have been a costly interception with 3:57 left, the Cardinals defense forced a turnover on down with 1:53 left and held on for the victory. 

Shough completed 28 of 38 passes for 322 yards and two touchdowns with two interceptions in the victory, finding Ja'Corey Brooks eight times for 120 yards. Isaac Brown added 85 yards and two touchdowns on 18 carries. Louisville scored the final 21 points with Shough finding Nate Kurisky for two scores and Brown having an 18-yard rushing touchdown. The Cardinals are 0-2 against ranked opponents, but they lost each game by just seven points in contest with Miami and Notre Dame, so they have proven the ability to play close with perceived stronger teams. Louisville (5-3) hasn't lost a game by more than seven points this season. See which team to pick here.

Why Clemson can cover

Since the Tigers' 34-3 loss to Georgia in the first game of the season, Clemson has been one of the most dominant teams in college football. The Tigers have won six straight since the opening loss by an average of 27.3 points per game, outscoring opponents 291-127. They've won each game by at least 16 points with four victories of 24 points or greater. Junior Cade Klubnik has thrown for more than 300 yards in back-to-back contests and he's completed 66.7% of his passes for 262.3 yards per game with 20 touchdowns compared to three interceptions this season.

Clemson is 8-0 all-time against Louisville, dating back to 2014. The Tigers defeated Louisville, 31-16, in their last meeting in 2022 and have beaten the Cardinals by an average of 28.6 points over their last five matchups. The Tigers are 3-1 against the spread as a home favorite this season, favored by double-digit points in each contest, and have the talent to run away with another lopsided victory over Louisville on Saturday. See which team to pick here.

How to make Clemson vs. Louisville picks

The model has simulated Louisville vs. Clemson 10,000 times and the results are in. The model is leaning Under, and it's also generated a point-spread pick that is hitting in almost 60% of simulations. You can only see the pick at SportsLine.

So who wins Clemson vs. Louisville, and which side of the spread is hitting almost 60% of the time? Visit SportsLine now to see which side of the Louisville vs. Clemson spread to jump on, all from the advanced computer model that's up well over $2,000 on its top-rated college football spread picks since its inception, and find out.