Duke vs. Florida State prediction, odds, line: 2024 Week 8 college football picks, best bets by proven model

SportsLine's model revealed its CFB picks and predictions for Duke Blue Devils vs. Florida State Seminoles on Friday

Two ACC rivals looking to get back in the win column face off on Friday when the Duke Blue Devils (5-1, 1-1) host the Florida State Seminoles (1-5, 1-1). Both teams are coming out of their bye weeks and lost their Week 6 contests. The Blue Devils suffered their first loss of the season ahead of the break, falling 24-14 loss to Georgia Tech. Meanwhile, the Seminoles look to snap a two-game losing skid that includes a 29-13 setback to Clemson their last time out.

Kickoff at Wallace Wade Stadium in Durham, N.C., is scheduled for 7 p.m. ET. The Blue Devils are 3-point favorites in the latest Florida State vs. Duke odds via SportsLine consensus, while the over/under for total points scored is 42.5. Duke is a -153 (risk $153 to win $100) favorite on the money line, with Florida State listed as a +127 underdog. Before making any Duke vs. Florida State picks, you need to see the college football predictions and betting advice from the SportsLine Projection Model.

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks and it is 12-5 on top-rated picks over the past three weeks of this season. Anyone who has followed it on betting sites has seen strong returns.

Now, the model has dialed in on Duke vs. Florida State and just revealed its coveted picks and predictions. You can head to SportsLine now to see the model's picks. Here are the college football betting lines and trends for Florida State vs. Duke.

• Duke vs. Florida State spread: Blue Devils -3
• Duke vs. Florida State over/under: 42.5 points 
• Duke vs. Florida State money line: Duke -153, FSU +127
• Duke: 2-1-2 ATS this season 
• FSU: 2-4-0 ATS this season 
• Duke vs. Florida State picks: See picks here
• Duke vs. Florida State streaming: FuboTV (Try for free)

Why Florida State can cover

Florida State has a psychological advantage heading into Friday's game. The Seminoles have never been beaten by the Blue Devils and carry a 22-0 all-time record into Wallace Wade Stadium. FSU has outscored Duke 58-26 over their last two meetings in North Carolina and won 38-20 when these teams faced off in Tallahassee last season.

The Seminoles look to Brock Glenn to have another solid outing in place of the injured DJ Uiagalelei (hand). The freshman quarterback for 228 yards with two touchdowns and one interception against Clemson ahead of the bye week. He has had two weeks to prepare for Friday's game, and FSU hopes the extra time allows him to lead the Seminoles to victory against Duke. See who to back at SportsLine.

Why Duke can cover

The Blue Devils have a 3-0 home record this season and are 2-1-2 against the spread in 2024. They can contribute some of that success to quarterback Maalik Murphy, who has been a standout since transferring from Texas. In his first season at Duke, Murphy has logged 1,431 passing yards with 14 touchdowns and five interceptions. Running back Star Thomas has managed the game on the ground, as the New Mexico State transfer has rushed for 528 yards on 113 carries and scored three touchdowns.

Duke also has the upper hand when it comes to defense. The Blue Devils are second in the ACC in total yards allowed per game (309.3) and points allowed per game (17.5). Linebacker Alex Howard leads Duke's defense with 47 total tackles, and he will keep FSU's offensive line busy on Friday. See who to back at SportsLine.

How to make Duke vs. Florida State picks

SportsLine's model is leaning Over on the total, projecting 47 combined points. It also says one side of the spread hits well over 50% of the time. You can see the model's pick at SportsLine.

So who wins Florida State vs. Duke, and which side of the spread hits well over 50% of the time? Visit SportsLine now to see which side of the spread to jump on, all from the advanced model that is up well over $2,000 on top-rated spread picks since its inception, and find out.