Jets vs. Bills odds, spread, line, prediction: Monday Night Football picks by NFL model on 191-131 run

SportsLine's model has simulated New York vs. Buffalo on Monday Night Football 10,000 times and revealed its MNF picks and predictions

An AFC East collision will happen on Monday Night Football as the New York Jets (2-3) host the Buffalo Bills (3-2). The winner of this game moves into first place in the division. Last Tuesday, the Jets fired head coach Robert Saleh and Jeff Ulbrich was been named the interim coach. Last week, the Jets fell to the Minnesota Vikings 23-17 in London. Buffalo also lost in Week 5, as the Houston Texans topped the Bills, 23-20. 

Kickoff from MetLife Stadium in New Jersey is set for 8:15 p.m. ET. Buffalo is a one-point favorite in the latest Bills vs. Jets odds from the SportsLine Consensus, while the over/under for total points scored is 41. Before locking in any Bills vs. Jets picks, make sure to check out the NFL predictions and betting advice from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 6 of the 2024 NFL season on an incredible 10-2 hot streak on top-rated NFL picks this year. Longer term, it is on a 191-131 roll on top-rated NFL picks that dates back to the 2017 season and a 45-23 roll on top-rated NFL picks since Week 7 of 2022.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has simulated Bills vs. Jets 10,000 times and just revealed its coveted NFL picks and Week 6 betting predictions. You can head to SportsLine now to see the model's picks. Here are several NFL odds and NFL betting lines for the spread, money line and over/under for Jets vs. Bills:

• Jets vs. Bills spread: Buffalo -1
• Jets vs. Bills over/under: 41 points
• Jets vs. Bills money line: Buffalo -120, New York +100
• BUF: Bills have scored last in four of their last five away games
• NYJ: Jets have hit the 4Q Game Total Under in 11 of their last 18 games 
• Jets vs. Bills picks: See picks at SportsLine
• Jets vs. Bills streaming: FuboTV (Try for free)

Why the Bills can cover

Quarterback Josh Allen is a dynamic signal-caller who owns a rocket of an arm, but will use his legs to pick up yards as well. The two-time Pro Bowl selection is tied for fifth in the league in passing touchdowns (8) and is first in QBR (77.6).

Running back James Cook (questionable, foot/toe) has emerged as a critical weapon in the offense. Cook has strong vision and agility in open space. The Georgia product also gives the team a weapon in the passing game. He has a team-high 309 rushing yards, 123 receiving yards and six total touchdowns. Last week, Cook had 82 rushing yards, 17 receiving yards and one score. See who to back at SportsLine.

Why the Jets can cover

The Jets are looking to get back into the win column and snap a two-game skid. The offense has struggled, but quarterback Aaron Rodgers is still a four-time MVP. Rodgers owns a quick release and can make any throw on the field. This season, he has completed 61% of his throws for 1,093 passing yards and seven passing touchdowns. Rodgers has thrown for at least 240 passing yards with two passing touchdowns in two of the last three games. 

Receiver Garrett Wilson is a shifty pass-catcher with the athleticism to make defenders miss. The Ohio State product leads the team in receptions (33) and receiving yards (292) with two receiving scores. In his last outing, Wilson had 13 catches for 101 yards and one touchdown. See who to back at SportsLine.

How to make Bills vs. Jets picks

SportsLine's model is leaning Over the total, projecting 41 combined points. The model also says one side of the spread hits more than 50% of the time. You can head to SportsLine to see the model's picks. 

So who wins Bills vs. Jets on Monday Night Football, and which side of the spread hits more than 50% of the time? Visit SportsLine now to see which side of the Bills vs. Jets spread to back, all from the model that has returned well over $7,000 on top-rated NFL picks, and find out.